Atatus python agent works automatically with frameworks. If your python app don't use any framework, then you should follow below steps.

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import atatus

client = atatus.Client({
        'APP_NAME': 'Your App',
        'LICENSE_KEY': 'lic_apm_*********'
    });

# Note: You have to manualy call instrument method when the app don't use any framework
atatus.instrument();

def handle_request():
    # Note: You have to begin and end transaction to record performance metrics
    client.begin_transaction("request");
    atatus.set_transaction_name("/user/create");

    # TODO: your code here

    client.end_transaction();